Resistin-like betais aproteinthat in humans is encoded by theRETNLBgene. An infusion of either resistin or RELMB in rats rapidly induced severe hepatic but not peripheral insulin resistance. Increases in circulating resistin or RELMB levels markedly stimulated hepatic glucose production despite the presence of fixed physiologic insulin levels. This enhanced rate of glucose output was due to increased flux through glucose-6-phosphatase. The results supported the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action.
Immunogen Information
Immunogen
Recombinant protein of human RETNLB
Swissprot
Q9BQ08
Synonyms
C/EBP epsilon regulated myeloid specific secreted cysteine rich protein precursor 2CCGRColon and small intestine specific cysteine rich proteinColon and small intestine-specific cysteine-rich proteinColon carcinoma related gene proteinColon carcinoma
Gene Accession
BC113502
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4