This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
Immunogen Information
Immunogen
Recombinant protein of human RGS1
Swissprot
Q08116
Synonyms
1R20B cell activation protein BL34B-cell activation protein BL34BL34Early response protein 1R20IER 1IER1Immediate early response 1 B cell specificimmediate-early response 1B-cell specificIR20Regulator of G protein signalling 1Regulator of G-p
Calculated MW
24 kDa
Gene Accession
BC015510
Applications
Reactivity
Human,Mouse
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4