Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.RHOB is a member of the Rho GTP-binding protein family.Mediates apoptosis in neoplastically transformed cells after DNA damage. It is not necessary for development but affects cell adhesion and growth factor signaling in transformed cells. It plays a negative role in tumorigenesis as deletion causes tumor formation. It involved in intracellular protein trafficking of a number of proteins, and serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Immunogen Information
Immunogen
Synthetic peptide of human RHOB
Swissprot
P62745
Synonyms
Aplysia RAS-related homolog 6ARH6ARHBH6MST081MSTP081oncogene RHO H6ras homolog family member Bras homolog gene familymember BRho cDNA clone 6Rho related GTP binding protein RhoB PrecursorRho-related GTP-binding protein RhoBRhobRHOBRHOH6
Calculated MW
22 kDa
Gene Accession
NP_004031
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:2000
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4