RNF111 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD218773A
Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using RNF111 Polyclonal Antibody at dilution of 1:50(×200)
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using RNF111 Polyclonal Antibody at dilution of 1:50(×200)
Product Name
RNF111 Polyclonal Antibody
Catalog Number
RD218773A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Immunogen Information
Immunogen
Fusion protein of human RNF111
Swissprot
Q6ZNA4
Synonyms
ARKArkadiaDKFZp313E0731DKFZp686H1966DKFZp761D081E3 ubiquitin protein ligase ArkadiaE3 ubiquitin-protein ligase ArkadiaFLJ38008RING finger protein 111RN111RNF 111RNF111
Gene Accession
BC010369
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:300, ELISA 1:5000-1:10000
Concentration
0.84 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas