This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen Information
Immunogen
Synthetic peptide of human ROR1
Swissprot
Q01973
Synonyms
dJ537F10.1Inactive tyrosine protein kinase transmembrane receptor ROR1MGC99659Neurotrophic tyrosine kinaseNeurotrophic tyrosine kinase receptor related 1Neurotrophic tyrosine kinasereceptor related 1NTRKR1OTTHUMP00000010573OTTHUMP00000010574OTTM
Gene Accession
NP_005003
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-1:100
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4