SAG Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
Immunohistochemistry of paraffin-embedded Mouse retina using SAG Polyclonal Antibody at dilution of  1:200 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse retina using SAG Polyclonal Antibody at dilution of 1:200 (40x lens).
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Overview

Circle
Product Name
SAG Polyclonal Antibody
Catalog Number
RD265995A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

Immunogen Information

Circle
Immunogen
Recombinant fusion protein of human SAG (NP_000532.2).
Gene ID
6295
Swissprot
P10523
Synonyms
SAGRP47S-AG

Applications

Circle
Reactivity
Mouse,Rat
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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