SARS-CoV-2 NSP3 Polyclonal Antibody(2019-nCoV)
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD90435A
Product Name
SARS-CoV-2 NSP3 Polyclonal Antibody(2019-nCoV)
Catalog Number
RD90435A
Clonality
Polyclonal
Purification Method
Produced in rabbits immunized with purified,Recombinant SARS-CoV-2 NSP3 protein
Isotype
IgG
Host
Rabbit
Background
Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.
Immunogen Information
Immunogen
Recombinant SARS-CoV-2 NSP3
Synonyms
Non-structural protein 3PL2-PROPapain-like proteinasePL-PROReplicase polyprotein 1a
Applications
Reactivity
SARS-COV2
Tested Applications
ELISA
Conjugation
Unconjugated
Dilution
ELISA 1:4000-1:8000
Concentration
0.33mg/mL
Storage Buffer
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.