SARS-CoV-2 Spike RBD (Bebtelovimab biosimilar) Neutralizing Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
Immobilized Recombinant SARS-CoV-2 Spike RBD Protein (N-His Tag)(Omicron) at 2.0 ug/mL (100 uL/well) can bind SARS-CoV-2 Spike RBD (Bebtelovimab biosimilar) Neutralizing Antibody, the EC50 is 0.1121 ug/mL.
Immobilized Recombinant SARS-CoV-2 Spike RBD Protein (N-His Tag)(Omicron) at 2.0 ug/mL (100 uL/well) can bind SARS-CoV-2 Spike RBD (Bebtelovimab biosimilar) Neutralizing Antibody, the EC50 is 0.1121 ug/mL.
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Overview

Circle
Product Name
SARS-CoV-2 Spike RBD (Bebtelovimab biosimilar) Neutralizing Antibody
Catalog Number
RD90430A
Purification Method
Protein A purification
Isotype
IgG
Host
Human

Background

Circle
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Immunogen Information

Circle
Synonyms
SARS-CoV-2 Surface GlycoproteinRBDSpkie protein

Applications

Circle
Reactivity
SARS-COV2
Tested Applications
ELISA
Conjugation
Unconjugated
Dilution
ELISA 1:5000-1:10000
Concentration
1 mg/mL
Storage Buffer
PBS,pH7.4
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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