Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
Immunogen Information
Immunogen
Synthetic peptide of human SCN11A
Swissprot
Q9UI33
Synonyms
hNaNNaNNAV1.9Peripheral nerve sodium channel 5PN 5PN5SCN 11ASCN 12AScn11aSCN12ASCNBASensory neuron sodium channel 2SNS 2SNS2Sodium channel protein type 11 subunit alphaSodium channel protein type XI subunit alphaSodium channel voltage gate
Gene Accession
NP_054858.2
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4