Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
Immunogen Information
Immunogen
Synthetic peptide of human SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/13A
Swissprot
P35498
Synonyms
brain sodium channel type IEIEE6FEB3FEB3AFHM3GEFS+2GEFSP2HBSC IHBSCINAC1Nav 1.1RBISCN1Scn1aSCN1ASMEISodium channel protein brain I alpha subunitSodium channel protein brain I subunit alphaSodium channel protein type 1 subunit alphaSodiu
Gene Accession
NP_001159435
Applications
Reactivity
Human,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4