Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
Immunogen Information
Immunogen
Synthetic peptide of human SDHB
Swissprot
P21912
Synonyms
CWS2DHSBFLJ92337IpIron sulfur subunitIron sulfur subunit of complex IIIron-sulfur subunit of complex IImitochondrialPGL 4PGL4SDH 1SDHSDH1SDH2SDH2homolog ofSdhBSDHIPSuccinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrialSu
Calculated MW
32 kDa
Gene Accession
NP_002991
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4