This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.
Immunogen Information
Immunogen
Synthetic peptide of human SEPT4
Swissprot
O43236
Synonyms
Apoptosis-related protein in the TGF-beta signaling pathwayARTSBradeionBradeion betaBrain protein H5CE5B3CE5B3 betaCell division control-related protein 2Cerebral protein 7H5hCDCREL-2hucep-7MARTPeanut-like protein 2PNUTL2SEP 4SEP4Sept4SE
Gene Accession
NP_004565
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4