Maspin (mammary serine protease inhibitor) also known as serpin B5 is a protein that in humans is encoded by the SERPINB5 gene.[1] This protein belongs to the serpin (serine protease inhibitor) superfamily.[1] SERPINB5 also functions as a tumor suppressor gene in epithelial cells. The expressed protein suppresses the ability of cancer cells to invade and metastasize other tissues. The protein also functions as an angiogenesis inhibitor.It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Immunogen Information
Immunogen
Recombinant protein of human SERPINB5
Swissprot
P36952
Synonyms
MaspinOvalbuminPeptidase inhibitor 5PI-5PI5protease inhibitor 5 (maspin)Protease inhibitor 5Serine (or cysteine) peptidase inhibitorclade Bmember 5serine (or cysteine) proteinase inhibitorclade B (ovalbumin)member 5Serpin B5serpin family B m
Calculated MW
42 kDa
Gene Accession
BC020713
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000, IHC 1:100-1:300
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4