This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Fusion protein of human SETMAR
Swissprot
Q53H47
Synonyms
Histone lysine N methyltransferaseHistone lysine N methyltransferase SETMARHsmar 1Hsmar1Mariner transposase Hsmar1MetnaseSET domain and mariner transposase fusionSET domain and mariner transposase fusion geneSET domain and mariner transposase fusi