SF3B3 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using SF3B3 Polyclonal Antibody at dilution of 1:70(×200)
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SF3B3 Polyclonal Antibody at dilution of 1:70(×200)
Product Name
SF3B3 Polyclonal Antibody
Catalog Number
RD219022A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Immunogen Information
Immunogen
Fusion protein of human SF3B3
Swissprot
Q15393
Synonyms
KIAA0017Pre mRNA splicing factor SF3b 130 kDa subunitPre-mRNA-splicing factor SF3b 130 kDa subunitRSE1SAP 130SAP130SF3b130SF3B3SF3B3_HUMANSpliceosome associated protein 130Spliceosome-associated protein 130Splicing factor 3b subunit 3 130kDSpl
Gene Accession
BC000463
Applications
Reactivity
Human, Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:300, ELISA 1:5000-1:10000
Concentration
1.2 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas