The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein of human PTPN11
Swissprot
Q06124
Synonyms
BPTP3CFCJMMLMETCDSMGC14433NS1OTTHUMP00000166107OTTHUMP00000166108Protein tyrosine phosphatase 2Protein tyrosine phosphatase 2CProtein tyrosine phosphatase non receptor type 11Protein-tyrosine phosphatase 1DProtein-tyrosine phosphatase 2CPTN11
Calculated MW
68 kDa
Gene Accession
BC008692
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4