TheSIGLEC6gene to 19q13.3, which is where the CD33 gene is located. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
Immunogen Information
Immunogen
Fusion protein of human SIGLEC6
Swissprot
O43699
Synonyms
CD327CD33 antigen-like 1CD33LCD33L1CD33L2CDw327OB-BP1OBBP1Obesity-binding protein 1Sialic acid-binding Ig-like lectin 6SIGL6Siglec-6SIGLEC6