This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
Immunogen Information
Immunogen
Recombinant protein of human SKP1
Swissprot
P63208
Synonyms
Cyclin A/CDK2 associated p19Cyclin A/CDK2 associated protein p19Cyclin-A/CDK2-associated protein p19EMC19MGC34403OCP 2OCP IIOCP II proteinOCP-2OCP-IIOCP2OCPIIOrgan of Corti protein 2Organ of Corti protein IIOTTHUMP00000159379OTTHUMP00000159
Calculated MW
19 kDa
Gene Accession
BC009839
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.1 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4