SLC22A17 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD78758A
Western Blot analysis of Human esophagus cancer tissue using SLC22A17 Polyclonal Antibody at dilution of 1:600
Immunohistochemistry of paraffin-embedded Human esophagus cancer using SLC22A17 Polyclonal Antibody at dilution of 1:30
Immunohistochemistry of paraffin-embedded Human cervical cancer using SLC22A17 Polyclonal Antibody at dilution of 1:30
Product Name
SLC22A17 Polyclonal Antibody
Catalog Number
RD78758A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Immunogen Information
Immunogen
Synthetic peptide of human SLC22A17
Swissprot
Q8WUG5
Synonyms
24p3 receptor24p3RBOCTBOITBrain type organic cation transporterBrain-type organic cation transporterhBOITLipocalin-2 receptorNeutrophil gelatinase associated lipocalin receptorNeutrophil gelatinase-associated lipocalin receptorNGAL receptorNgal
Calculated MW
56 kDa
Gene Accession
NP_065105.2
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas