The protein involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids .Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.
Immunogen Information
Immunogen
Synthetic peptide of human SLC27A1
Swissprot
Q6PCB7
Synonyms
ACSVL5FATP 1FATPFATP1Fatty acid transport protein 1FLJ00336Long chain fatty acid transport protein 1MGC71751SLC27A1Solute carrier family 27 (fatty acid transporter) member 1Solute carrier family 27 member 1
Gene Accession
NP_940982.1
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4