SMAD7 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD78637A
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SMAD7 Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SMAD7 Polyclonal Antibody at dilution 1:40
Product Name
SMAD7 Polyclonal Antibody
Catalog Number
RD78637A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human SMAD7
Swissprot
O15105
Synonyms
CRCS3FLJ16482hSMAD 7hSMAD7MAD (mothers against decapentaplegic Drosophila) homolog 7MADMad homolog 7MAD homolog 8MAD mothers against decapentaplegic homolog 7MADH 7MADH 8MADH6MADH8Mothers Against Decapentaplegic Drosophila Homolog of 6Mother
Gene Accession
NP_005895
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas