SMG8 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD76477A
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using SMG8 Polyclonal Antibody at dilution 1:50
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using SMG8 Polyclonal Antibody at dilution 1:50
Variation
Quantity
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Overview
Product Name
SMG8 Polyclonal Antibody
Catalog Number
RD76477A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
Immunogen Information
Immunogen
Synthetic peptide of human SMG8
Swissprot
Q8ND04
Synonyms
ABC 2ABC2Amplified in breast cancer gene 2 proteinChromosome 17 open readingchromosome 17 open reading frame 71FLJ10587Protein smg 8 homologprotein SMG8SMG8SMG8 protein
Gene Accession
NP_060619
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-1:100
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas