This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED).
Immunogen Information
Immunogen
Fusion protein of human SNIP1
Swissprot
Q8TAD8
Synonyms
FHA domain containing protein SNIP1FHA domain-containing protein SNIP1FLJ12553PMREDSmad nuclear interacting protein (Smad nuclear interacting)smad nuclear interacting protein 1Smad nuclear interacting proteinSmad nuclear-interacting protein 1SNIP