SOCS1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD76425A
Western Blot analysis of 231 cell using SOCS1 Polyclonal Antibody at dilution of 1:1300
Immunohistochemistry of paraffin-embedded Human ovarian cancer using SOCS1 Polyclonal Antibody at dilution of 1:70
Immunohistochemistry of paraffin-embedded Human gastric cancer using SOCS1 Polyclonal Antibody at dilution of 1:70
Product Name
SOCS1 Polyclonal Antibody
Catalog Number
RD76425A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Immunogen Information
Immunogen
Synthetic peptide of human SOCS1
Swissprot
O15524
Synonyms
CISH 1CISH1Cytokine inducible SH2 protein 1JABJAK binding proteinJAK-binding proteinJanus kinase binding proteinSOCS 1SOCS-1Socs1SOCS1SSI 1SSI-1SSI1STAT induced STAT inhibitor 1STAT-induced STAT inhibitor 1Suppressor of cytokine signaling
Calculated MW
24 kDa
Gene Accession
NP_003736
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000, IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.