The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
Immunogen Information
Immunogen
Recombinant protein of human SOCS6
Swissprot
O14544
Synonyms
CIS-4CIS4Cish4Cytokine inducible SH2 protein 4Cytokine-inducible SH2 protein 4HSPC060SOCS-4SOCS-6SOCS4Socs6SOCS6SSI4STAI4STAT induced STAT inhibitor 4STAT4STATI4Suppressor of cytokine signaling 4Suppressor of cytokine signaling 6
Gene Accession
BC020082
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4