The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant protein of human SPDEF
Swissprot
O95238
Synonyms
bA375E1.3PDEFProstate derived Ets factorPROSTATE EPITHELIUM SPECIFIC ETS TRANSCRIPTION FACTORProstate epithelium-specific Ets transcription factorProstate specific EtsProstate-derived Ets factorProstate-specific EtsPSERP11-375E1__A.3SAM POINTED
Gene Accession
BC021299
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4