SRGAP3 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD76121A
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SRGAP3 Polyclonal Antibody at dilution 1:40
Product Name
SRGAP3 Polyclonal Antibody
Catalog Number
RD76121A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Immunogen Information
Immunogen
Recombinant protein of human SRGAP3
Swissprot
O43295
Synonyms
ARHGAP 14ARHGAP14GbiME GAPMEGAPMental disorder associated GAPMental disorder-associated GAPRho GTPase activating protein 14Rho GTPase-activating protein 14SLIT ROBO Rho GTPase activating protein 3SLIT-ROBO Rho GTPase-activating protein 3srGAP 2
Gene Accession
BC039300
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-1:100
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas