The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus.
Immunogen Information
Immunogen
Synthetic peptide of human SSB
Swissprot
P05455
Synonyms
Autoantigen LaLaLa autoantigenLa autoantigen homologLa proteinLa ribonucleoproteinLa ribonucleoprotein domain family member 3LALARP3Lupus La antigenLupus La proteinLupus La protein homologMGC118101MGC93380mRNA for autoantigenOTTMUSP0000001
Calculated MW
47 kDa
Gene Accession
NP_003133
Applications
Reactivity
Human
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4