The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.
Immunogen Information
Immunogen
Recombinant protein of human STAR
Swissprot
P49675
Synonyms
Cholesterol traffickerLuteinizing hormone induced proteinmitochondrialMitochondrial steroid acute regulatory proteinStARStAR related lipid transfer (START) domain containing 1STARStARD1START domain containing 1START domain containing protein 1ST
Calculated MW
32 kDa
Gene Accession
BC010550
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000, IHC 1:25-1:100
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4