The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Recombinant protein of human STAT6
Swissprot
P42226
Synonyms
12S1644D12S1644IL 4 STATIL-4 StatIL4 STATInterleukin 4 InducedInterleukin 4 Induced Transcription Factor IL4 STATSignal transducer and activator of transcription 6Signal Transducer And Activator Of Transcription 6 Interleukin 4 InducedSignal Tran
Calculated MW
94 kDa
Gene Accession
BC075852
Applications
Reactivity
Human,Mouse
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4