TAB1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD78229A
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TAB1 Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TAB1 Polyclonal Antibody at dilution 1:40
Product Name
TAB1 Polyclonal Antibody
Catalog Number
RD78229A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.
Immunogen Information
Immunogen
Recombinant protein of human TAB1
Swissprot
Q15750
Synonyms
2310012M03Rik3'-Tab1MAP3K7IP 1MAP3K7IP1MGC57664Mitogen activated protein kinase kinase kinase 7 interacting protein 1Mitogen-activated protein kinase kinase kinase 7-interacting protein 1TAB 1TAB1TAB1TAK1 binding protein 1TAK1-binding protein 1
Gene Accession
BC050554
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.2 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas