TAB2 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
Western blot analysis of extracts of various cell lines using TAB2 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using TAB2 Polyclonal Antibody at 1:1000 dilution.
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For more information on our kits, please contact us at info@reddotbiotech.com

Overview

Circle
Product Name
TAB2 Polyclonal Antibody
Catalog Number
RD90029A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.

Immunogen Information

Circle
Immunogen
Recombinant fusion protein of human TAB2
Gene ID
23118
Swissprot
Q9NYJ8
Synonyms
TAB2CHTD2MAP3K7IP2TAB-2
Calculated MW
119kDa/133kDa
Observed MW
150kDa

Applications

Circle
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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