TAF1 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD88306A
Western blot analysis of extracts of various cell lines using TAF1 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using TAF1 Polyclonal Antibody at 1:1000 dilution.
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Overview

Circle
Product Name
TAF1 Polyclonal Antibody
Catalog Number
RD88306A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N-and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons.

Immunogen Information

Circle
Immunogen
Recombinant fusion protein of human TAF1
Gene ID
6872
Swissprot
P21675
Synonyms
TAF1BA2RCCG1CCGSDYT3DYT3/TAF1KAT4MRXS33N-TAF1NSCL2OFP250TAF(II)250TAF2ATAFII-250TAFII250XDP
Calculated MW
62kDa/66kDa/73kDa
Observed MW
70kDa

Applications

Circle
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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