TAP2 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD82232A
Immunofluorescence analysis of U2OS cells using TAP2 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using TAP2 Polyclonal Antibody
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Overview

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Product Name
TAP2 Polyclonal Antibody
Catalog Number
RD82232A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

Immunogen Information

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Immunogen
Recombinant fusion protein of human TAP2 (NP_000535.3).
Gene ID
6891
Swissprot
Q03519
Synonyms
TAP2ABC18ABCB3APT2D6S217EPSF-2PSF2RING11

Applications

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Reactivity
Human,Mouse,Rat
Tested Applications
IF
Conjugation
Unconjugated
Dilution
IF 1:50-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

Research Areas

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