Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Immunogen Information
Immunogen
Synthetic Peptide of Tau
Swissprot
P10636
Synonyms
AI413597AW045860DDPACFLJ31424FTDP 17G protein beta1/gamma2 subunit interacting factor 1MAPTMAPTLMGC134287MGC138549MGC156663Microtubule associated protein tauMicrotubule associated protein tau isoform 4Microtubule-associated protein tauMSTDM
Observed MW
79 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p
Conjugation
Unconjugated
Dilution
WB 1:1000-2000, IHC 1:100-200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4