The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.
Immunogen Information
Immunogen
Recombinant human T-complex protein 1 subunit alpha protein
Swissprot
P17987
Synonyms
AI528772c-cpnCCT alphaCCTCCT-alphaCCT1CctaCCTalphaD6S230EMGC133746p63T complex 1T complex protein 1 alpha subunitT complex protein 1T-complex homolog TCP1T-complex protein 1 subunit alphaT-complex protein 1 subunit alpha BTailless complex
Calculated MW
60 kDa
Observed MW
60 kDa
Applications
Reactivity
Human
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:1000, IHC 1:50-1:100
Concentration
2 mg/mL
Storage Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.