This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
Immunogen Information
Immunogen
Fusion protein of human TERF1
Swissprot
P54274
Synonyms
hTRF1 ASNIMA interacting protein 2NIMA-interacting protein 2PIN 2PIN2t TRF1Telomeric protein Pin2Telomeric protein Pin2/TRF1Telomeric repeat binding factor (NIMA interacting) 1Telomeric repeat binding factor 1Telomeric repeat binding protein 1T