Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+/H(+ exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Immunogen Information
Immunogen
Recombinant fusion protein of human TESC
Gene ID
54997
Swissprot
Q96BS2
Synonyms
TESCCHP3TSCtescalcin
Calculated MW
18kDa/49kDa/72kDa/74kDa
Observed MW
72kDa
Applications
Reactivity
Human
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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