Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
Immunogen Information
Immunogen
Synthetic peptide of human TG
Swissprot
P01266
Synonyms
AITD 3AITD3hTGTDH3TgTGNTHYGThyroglobulin
Gene Accession
NP_003226
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-1:150
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4