TGFB1 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD233090A
Western Blot analysis of MCF7 cells using TGFB1 Polyclonal Antibody at dilution of 1:2000.
Western Blot analysis of MCF7 cells using TGFB1 Polyclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TGFB1 Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TGFB1 Polyclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Rat lung tissue using TGFB1 Polyclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Rat lung tissue using TGFB1 Polyclonal Antibody at dilution of 1:200.
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Overview

Circle
Product Name
TGFB1 Polyclonal Antibody
Catalog Number
RD233090A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.

Immunogen Information

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Immunogen
Synthesized peptide derived from the C-terminal region of human TGFβ1
Swissprot
P01137
Synonyms
Cartilage-inducing factorCEDDifferentiation inhibiting factorDPD1LAPLatency-associated peptidePrepro transforming growth factor beta 1TGF beta 1TGF betaTGF beta 1 proteinTGF-beta 1 proteinTGF-beta-1TGF-beta-5TGF-beta1TGFBTgfb-1tgfb1TGFB1
Calculated MW
44 kDa
Observed MW
44 kDa

Applications

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Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,IF,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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