The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant Rat TGF-beta receptor type-1 protein
Gene ID
29591
Swissprot
P80204
Synonyms
AAT5Activin A receptor type II like kinaseActivin receptor like kinase 5ACVRLK4ALK5LDS1ALDS2AMSSESKR4TGF beta receptor type 1TGFBR1 proteinTGFR1Transforming growth factor beta receptor 1