TGIF1 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD88717A
Western blot analysis of extracts of various cell lines using TGIF1 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using TGIF1 Polyclonal Antibody at 1:1000 dilution.
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Overview

Circle
Product Name
TGIF1 Polyclonal Antibody
Catalog Number
RD88717A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

Circle
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.

Immunogen Information

Circle
Immunogen
Recombinant fusion protein of human TGIF1
Gene ID
7050
Swissprot
Q15583
Synonyms
TGIF1HPE4TGIF
Calculated MW
8kDa/11kDa
Observed MW
90kDa

Applications

Circle
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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