The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Fusion protein of human THG1L
Swissprot
Q9NWX6
Synonyms
ICF45Interphase cytoplasmic foci protein 45Probable tRNA(His) guanylyltransferaseTHG1THG1LtRNA histidine guanylyltransferase 1 like (S. cerevisiae)tRNA-histidine guanylyltransferase