The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Immunogen Information
Immunogen
Full length fusion protein
Swissprot
P58753
Synonyms
Adapter protein wyattFLJ42305MALMyD88 adapter like proteinTIR domain containing adapter proteinToll interleukin 1 receptor (TIR) domain containing adaptor proteinToll interleukin 1 receptor domain containing adapter proteinToll like receptor adapto
Gene Accession
BC032474
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-100, ELISA 1:2000-5000
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4