This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Immunogen Information
Immunogen
Recombinant protein of human TLR5
Swissprot
O60602
Synonyms
FLJ10052MGC126430MGC126431SLEB1TIL 3TIL3TLR 5Tlr5TLR5Toll like receptor 5Toll like receptor 5 precursorToll-like receptor 5Toll/interleukin 1 receptor like protein 3Toll/interleukin-1 receptor-like protein 3
Gene Accession
BC109119
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4