B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Immunogen Information
Immunogen
Synthetic peptide of human TNFRSF13C
Swissprot
Q96RJ3
Synonyms
B cell activating factor receptorB-cell-activating factor receptorBAFF RBAFF receptorBAFF-RBAFFRBLyS receptor 3BlySR3BR 3BR3BROMIXCD 268CD268CD268 antigenCVID4MGC138235OTTHUMP00000028746ProlixinTNFRSF 13CTnfrsf13cTR13CTumor necrosis f
Gene Accession
NP_443177
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4