The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Immunogen Information
Immunogen
Synthetic peptide of human TNFRSF8
Swissprot
P28908
Synonyms
CD 30CD30CD30 antigenCD30L receptorCytokine receptor CD30D1S166EKI 1KI 1 antigenKi-1 antigenKI1Lymphocyte activation antigen CD30TNFRSF 8Tnfrsf8TNR8Tumor necrosis factor receptor superfamily member 8
Gene Accession
NP_001234
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4