This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Immunogen Information
Immunogen
Synthetic peptide of human TNK2
Swissprot
Q07912
Synonyms
Acetate kinase 1Acetokinase 1ACK 1ACKACK-1ACK1ACK1Activated Cdc42 associated kinase 1Activated CDC42 kinase 1Activated p21cdc42Hs kinaseFLJ44758FLJ45547p21cdc42HsTNK 2TNK2Tyrosine kinase non receptor 2Tyrosine kinase non receptor protein 2
Gene Accession
NP_005772
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4