The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
Immunogen Information
Immunogen
Recombinant protein of human TONSL
Swissprot
Q96HA7
Synonyms
I kappa B related proteinI-kappa-B-related proteinIkappaBRIKBRInhibitor of kappa B related proteinInhibitor of kappa B-related proteinMMS22L-interacting proteinMMS22L-interacting proteinNFBIL2/TONSLNF kappa B inhibitor like protein 2NF-kappa-B i
Gene Accession
BC008782
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:100-1:300
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4