TPMT Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD80261A
Western blot analysis of extracts of K562 cells using TPMT Polyclonal Antibody at dilution of 1:1000.
Product Name
TPMT Polyclonal Antibody
Catalog Number
RD80261A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Immunogen Information
Immunogen
Recombinant fusion protein of human TPMT (NP_000358.1).
Gene ID
7172
Swissprot
P51580
Synonyms
TPMTTPMTD
Calculated MW
28 kDa
Observed MW
28 kDa
Applications
Reactivity
Human
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas